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Like Most of its Sister Hormones, Melatonin Enhances Many Body
Functions.
The Many Benefits
of Melatonin
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Many researchers believe that levels of melatonin in the body are
related to the aging process. For example, young children have the
highest levels of nighttime melatonin and these levels are thought
to diminish progressively with age. This decline likely contributes
to why many older adults suffer from disrupted sleep patterns and
tend to go to bed earlier and wake up earlier in the morning than
when they were younger.
Melatonin keeps our circadian cycle in tune as it communicates with
the body’s cells. Not only does this hormone work to maintain cell
health, it appears to regulate a system of self-repair and
regeneration. When this hard-working hormone is diminished, our
biological functions are impaired.
The Oxford Textbook of Medicine Recommends Melatonin for Symptoms
of Jet lag.
An investigation was done into the efficacy of oral melatonin in
alleviating jet lag in flight crews after a series of international
flights. The optimal time for taking melatonin was also
investigated. When melatonin 5 mg was given on arrival for 5 days a
trend showing improved recovery in jet-lag, mood and sleepiness was
shown. There was also a significantly faster recovery of energy and
alertness.
Strong Antioxidant Properties
In addition to its hormone actions, melatonin also has strong
antioxidant properties and preliminary evidence suggests that it may
help strengthen the immune system.
May Help Regulate Menstrual Cycle
Melatonin is also one of the hormones that controls the timing and
release of female reproductive hormones. As a result, melatonin
helps determine when menstruation begins, the frequency and duration
of menstrual cycles, and when menstruation ends (menopause).
Multiple Benefits
Recent studies found melatonin to be effective in aiding sleep and
travel fatigue, but have often ignored its role as a powerful
antioxidant and its effectiveness as a free radical scavenger that
can stave off the effects of aging. Further new research has shown
that melatonin stimulates the natural production of human growth
hormones.
Melatonin releases from the pineal gland, reaching its peak at night
to help maintain tissues in a youthful state of health. Secretion of
melatonin declines significantly with age, as the pineal gland
becomes calcified.
Many people use melatonin to help improve sleep. Some research has
found that melatonin increases the speed of falling asleep and adds
to the quality of sleep in about 60% of people who use it. See the
following study.
Melatonin Sleep Study
Melatonin, produced by the pineal gland at night, has a role in
regulation of the sleep-wake cycle. Among elderly people, even those
who are healthy, the frequency of sleep disorders is high and there
is an association with impairment of melatonin production. We
investigated the effect of a controlled-release formulation of
melatonin on sleep quality in 12 elderly subjects (aged 76 [SD 8]
years) who were receiving various medications for chronic illnesses
and who complained of insomnia. In all 12 subjects the peak
excretion of the main melatonin metabolite 6-sulphatoxymelatonin
during the night was lower than normal and/or delayed in comparison
with non-insomniac elderly people. In a randomized, double-blind,
crossover study the subjects were treated for 3 weeks with 2 mg per
night of controlled-release melatonin and for 3 weeks with placebo,
with a week's washout period. Sleep quality was objectively
monitored by wrist actigraphy. Sleep efficiency was significantly
greater after melatonin than after placebo.
Improvement of sleep quality in elderly people by
controlled-release melatonin
Lancet ( ENGLAND ) Aug 26 1995 , 346 (8974) p541-4
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